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While the mechanism of action of amantadine in the treatment of parkinson s syndrome and drug-induced extrapyramidal reactions is not known, it is believed to release brain dopamine from nerve endings making it more available to activate dopaminergic receptors.
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Most information required to assess study quality was not reported in the amantadine trials.
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These concentrations represented 31 33 , 59 61 and 95 86 of the corresponding plasma amantadine concentrations.
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